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Mediator kinase inhibition reverses castration resistance of advanced prostate cancer.
Li J, Hilimire TA, Yueying L, Wang L, Liang J, Győrffy B, Sikirzhytski V, Ji H, Zhang L, Cheng C, Ding X, Kerr KR, Dowling CE, Chumanevich AA, Mack ZT, Schools GP, Lim CU, Ellis L, Zi X, Porter DC, Broude EV, McInnes C, Wilding G, Lilly MB, Roninson IB, Chen M. Li J, et al. Among authors: broude ev. J Clin Invest. 2024 Mar 28:e176709. doi: 10.1172/JCI176709. Online ahead of print. J Clin Invest. 2024. PMID: 38546787 Free article.
Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo.
Ding X, Sharko AC, McDermott MSJ, Schools GP, Chumanevich A, Ji H, Li J, Zhang L, Mack ZT, Sikirzhytski V, Shtutman M, Ivers L, O'Donovan N, Crown J, Győrffy B, Chen M, Roninson IB, Broude EV. Ding X, et al. Among authors: broude ev. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2201073119. doi: 10.1073/pnas.2201073119. Epub 2022 Aug 1. Proc Natl Acad Sci U S A. 2022. PMID: 35914167 Free PMC article.
Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.
Porter DC, Farmaki E, Altilia S, Schools GP, West DK, Chen M, Chang BD, Puzyrev AT, Lim CU, Rokow-Kittell R, Friedhoff LT, Papavassiliou AG, Kalurupalle S, Hurteau G, Shi J, Baran PS, Gyorffy B, Wentland MP, Broude EV, Kiaris H, Roninson IB. Porter DC, et al. Among authors: broude ev. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13799-804. doi: 10.1073/pnas.1206906109. Epub 2012 Aug 6. Proc Natl Acad Sci U S A. 2012. PMID: 22869755 Free PMC article.
CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.
Chen M, Liang J, Ji H, Yang Z, Altilia S, Hu B, Schronce A, McDermott MSJ, Schools GP, Lim CU, Oliver D, Shtutman MS, Lu T, Stark GR, Porter DC, Broude EV, Roninson IB. Chen M, et al. Among authors: broude ev. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10208-10213. doi: 10.1073/pnas.1710467114. Epub 2017 Aug 30. Proc Natl Acad Sci U S A. 2017. PMID: 28855340 Free PMC article.
Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer.
Serrao A, Jenkins LM, Chumanevich AA, Horst B, Liang J, Gatza ML, Lee NY, Roninson IB, Broude EV, Mythreye K. Serrao A, et al. Among authors: broude ev. Oncogene. 2018 Aug;37(35):4792-4808. doi: 10.1038/s41388-018-0316-y. Epub 2018 May 21. Oncogene. 2018. PMID: 29780169 Free PMC article.
CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases.
Liang J, Chen M, Hughes D, Chumanevich AA, Altilia S, Kaza V, Lim CU, Kiaris H, Mythreye K, Pena MM, Broude EV, Roninson IB. Liang J, et al. Among authors: broude ev. Cancer Res. 2018 Dec 1;78(23):6594-6606. doi: 10.1158/0008-5472.CAN-18-1583. Epub 2018 Sep 5. Cancer Res. 2018. PMID: 30185549 Free PMC article.
Identifying Cancers Impacted by CDK8/19.
Roninson IB, Győrffy B, Mack ZT, Shtil AA, Shtutman MS, Chen M, Broude EV. Roninson IB, et al. Among authors: broude ev. Cells. 2019 Aug 3;8(8):821. doi: 10.3390/cells8080821. Cells. 2019. PMID: 31382571 Free PMC article.
39 results