Gonzalez FJ - Search Results

1

Therapeutic efficacy of Wuzhi tablet (Schisandra sphenanthera Extract) on acetaminophen-induced hepatotoxicity through a mechanism distinct from N-acetylcysteine.

Fan X, Chen P, Jiang Y, Wang Y, Tan H, Zeng H, Wang Y, Qu A, Gonzalez FJ, Huang M, Bi H. Fan X, et al. Among authors: gonzalez fj. Drug Metab Dispos. 2015 Mar;43(3):317-24. doi: 10.1124/dmd.114.062067. Epub 2014 Dec 22. Drug Metab Dispos. 2015. PMID: 25534769 Free PMC article.

2

Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism.

Yang TJ, Krausz KW, Sai Y, Gonzalez FJ, Gelboin HV. Yang TJ, et al. Among authors: gonzalez fj. Drug Metab Dispos. 1999 Jan;27(1):102-9. Drug Metab Dispos. 1999. PMID: 9884317

3

The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity.

Cheung C, Yu AM, Ward JM, Krausz KW, Akiyama TE, Feigenbaum L, Gonzalez FJ. Cheung C, et al. Among authors: gonzalez fj. Drug Metab Dispos. 2005 Mar;33(3):449-57. doi: 10.1124/dmd.104.002402. Epub 2004 Dec 2. Drug Metab Dispos. 2005. PMID: 15576447

4

Metabolism of melatonin by human cytochromes p450.

Ma X, Idle JR, Krausz KW, Gonzalez FJ. Ma X, et al. Among authors: gonzalez fj. Drug Metab Dispos. 2005 Apr;33(4):489-94. doi: 10.1124/dmd.104.002410. Epub 2004 Dec 22. Drug Metab Dispos. 2005. PMID: 15616152

5

3,4-Dehydrodebrisoquine, a novel debrisoquine metabolite formed from 4-hydroxydebrisoquine that affects the CYP2D6 metabolic ratio.

Zhen Y, Slanar O, Krausz KW, Chen C, Slavík J, McPhail KL, Zabriskie TM, Perlík F, Gonzalez FJ, Idle JR. Zhen Y, et al. Among authors: gonzalez fj. Drug Metab Dispos. 2006 Sep;34(9):1563-74. doi: 10.1124/dmd.105.008920. Epub 2006 Jun 16. Drug Metab Dispos. 2006. PMID: 16782768 Free PMC article. Clinical Trial.

6

The 2006 Bernard B. Brodie Award Lecture. Cyp2e1.

Gonzalez FJ. Gonzalez FJ. Drug Metab Dispos. 2007 Jan;35(1):1-8. doi: 10.1124/dmd.106.012492. Epub 2006 Oct 4. Drug Metab Dispos. 2007. PMID: 17020953 Review.

7

The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.

Ma X, Shah Y, Cheung C, Guo GL, Feigenbaum L, Krausz KW, Idle JR, Gonzalez FJ. Ma X, et al. Among authors: gonzalez fj. Drug Metab Dispos. 2007 Feb;35(2):194-200. doi: 10.1124/dmd.106.012831. Epub 2006 Nov 8. Drug Metab Dispos. 2007. PMID: 17093002

8

Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.

Wolf KK, Wood SG, Allard JL, Hunt JA, Gorman N, Walton-Strong BW, Szakacs JG, Duan SX, Hao Q, Court MH, von Moltke LL, Greenblatt DJ, Kostrubsky V, Jeffery EH, Wrighton SA, Gonzalez FJ, Sinclair PR, Sinclair JF. Wolf KK, et al. Among authors: gonzalez fj. Drug Metab Dispos. 2007 Jul;35(7):1223-31. doi: 10.1124/dmd.107.014738. Epub 2007 Mar 28. Drug Metab Dispos. 2007. PMID: 17392391

9

Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice.

Chen C, Krausz KW, Idle JR, Gonzalez FJ. Chen C, et al. Among authors: gonzalez fj. J Biol Chem. 2008 Feb 22;283(8):4543-59. doi: 10.1074/jbc.M706299200. Epub 2007 Dec 19. J Biol Chem. 2008. PMID: 18093979 Free PMC article.

10

A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4.

Ma X, Cheung C, Krausz KW, Shah YM, Wang T, Idle JR, Gonzalez FJ. Ma X, et al. Among authors: gonzalez fj. Drug Metab Dispos. 2008 Dec;36(12):2506-12. doi: 10.1124/dmd.108.022723. Epub 2008 Sep 17. Drug Metab Dispos. 2008. PMID: 18799805 Free PMC article.

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