Send it, receive it, quick erase it: A mouse model to decipher chemokine communication

Leen Hermans; Timothy E O'Sullivan

doi:10.1084/jem.20240582

Send it, receive it, quick erase it: A mouse model to decipher chemokine communication

J Exp Med. 2024 Jul 1;221(7):e20240582. doi: 10.1084/jem.20240582. Epub 2024 May 7.

Authors

Leen Hermans¹, Timothy E O'Sullivan^{1

2}

Affiliations

¹ Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
² Molecular Biology Institute, University of California, Los Angeles , Los Angeles, CA, USA.

PMID: 38713202
PMCID: PMC11076807 (available on 2024-11-07)
DOI: 10.1084/jem.20240582

Abstract

A method to precisely determine which cells respond to chemokines in vivo is currently lacking. A novel class of dual fluorescence reporter mice could help identify cells that produce and/or sense a given chemokine in vitro and in vivo (Rodrigo et al. 2024. J. Exp. Med.https://doi.org/10.1084/jem.20231814).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chemokines* / metabolism
Mice
Models, Animal

Substances

Chemokines

Abstract

Publication types

MeSH terms

Substances

Grants and funding