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Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506).
Qin XL, Bi HC, Wang XD, Li JL, Wang Y, Xue XP, Chen X, Wang CX, Xu le J, Wang YT, Huang M. Qin XL, et al. Among authors: wang xd, wang yt, wang y, wang cx. Int J Pharm. 2010 Apr 15;389(1-2):114-21. doi: 10.1016/j.ijpharm.2010.01.025. Epub 2010 Jan 25. Int J Pharm. 2010. PMID: 20097278
In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A/P-glycoprotein-mediated absorption and metabolism of tacrolimus.
Qin XL, Chen X, Wang Y, Xue XP, Wang Y, Li JL, Wang XD, Zhong GP, Wang CX, Yang H, Huang M, Bi HC. Qin XL, et al. Among authors: wang xd, wang y, wang cx. Drug Metab Dispos. 2014 Jan;42(1):193-9. doi: 10.1124/dmd.113.053892. Epub 2013 Nov 6. Drug Metab Dispos. 2014. PMID: 24195812
Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways.
Fan X, Jiang Y, Wang Y, Tan H, Zeng H, Wang Y, Chen P, Qu A, Gonzalez FJ, Huang M, Bi H. Fan X, et al. Among authors: wang y. Drug Metab Dispos. 2014 Dec;42(12):1982-90. doi: 10.1124/dmd.114.059535. Epub 2014 Sep 12. Drug Metab Dispos. 2014. PMID: 25217484 Free PMC article.
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