Restoring multiple adjacent missing teeth in the anterior maxilla is one of the most challenging situations in clinical implant dentistry, as restorations need to be both functional and highly esthetic. The purpose of this article is to highlight the issues that arise during treatment planning for replacement of six missing maxillary anterior teeth with implant-supported fixed dental prostheses. Representative clinical reports are provided to illustrate the treatment planning and surgical and prosthodontic management. The authors describe the rationale for selecting the appropriate number and location of implants in relation to the amount of missing soft and hard tissues to achieve functional and esthetic prostheses.