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Page 1
Clinical and Preclinical Evidence for Functional Interactions of Cannabidiol and Δ9-Tetrahydrocannabinol.
Boggs DL, Nguyen JD, Morgenson D, Taffe MA, Ranganathan M. Boggs DL, et al. Among authors: taffe ma. Neuropsychopharmacology. 2018 Jan;43(1):142-154. doi: 10.1038/npp.2017.209. Epub 2017 Sep 6. Neuropsychopharmacology. 2018. PMID: 28875990 Free PMC article. Review.
There are >550 chemical compounds and >100 phytocannabinoids isolated from cannabis, including delta(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is thought to produce the main psychoactive effects of cannabis, while CBD does not appear to have sim …
There are >550 chemical compounds and >100 phytocannabinoids isolated from cannabis, including delta(9)-tetrahydrocannabinol (THC
Δ9-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions.
Nguyen JD, Grant Y, Creehan KM, Hwang CS, Vandewater SA, Janda KD, Cole M, Taffe MA. Nguyen JD, et al. Among authors: taffe ma. Neuropharmacology. 2019 Jun;151:127-135. doi: 10.1016/j.neuropharm.2019.04.010. Epub 2019 Apr 11. Neuropharmacology. 2019. PMID: 30980837 Free PMC article.
Additional groups of male and female Wistar rats were assessed for nociception following inhalation of vaporized THC (50 mg/mL), oxycodone (100 mg/mL) or the combination. Tail withdrawal latency was increased more by the THC/oxycodone combination compared to either …
Additional groups of male and female Wistar rats were assessed for nociception following inhalation of vaporized THC (50 mg/mL), oxyc …
Effects of combined THC and heroin vapor inhalation in rats.
Gutierrez A, Nguyen JD, Creehan KM, Javadi-Paydar M, Grant Y, Taffe MA. Gutierrez A, et al. Among authors: taffe ma. Psychopharmacology (Berl). 2022 May;239(5):1321-1335. doi: 10.1007/s00213-021-05904-w. Epub 2021 Jun 23. Psychopharmacology (Berl). 2022. PMID: 34160641 Free PMC article.
RESULTS: Heroin inhalation increased temperature and activity whereas THC inhalation decreased temperature and activity in both female and male Sprague-Dawley rats. Effects of combined inhalation were in opposition, and additional experiments found the same outcome for the …
RESULTS: Heroin inhalation increased temperature and activity whereas THC inhalation decreased temperature and activity in both femal …
Effects of delta9-tetrahydrocannabinol (THC) vapor inhalation in Sprague-Dawley and Wistar rats.
Taffe MA, Creehan KM, Vandewater SA, Kerr TM, Cole M. Taffe MA, et al. Exp Clin Psychopharmacol. 2021 Feb;29(1):1-13. doi: 10.1037/pha0000373. Epub 2020 Apr 16. Exp Clin Psychopharmacol. 2021. PMID: 32297788 Free PMC article.
Hypothermic effects of THC were more pronounced in SD rats, where plasma levels of THC were identical across strains, under either fixed inhalation conditions or injection of a mg/kg equivalent dose. ...These studies confirm an insensitivity of WI rats, compared wit …
Hypothermic effects of THC were more pronounced in SD rats, where plasma levels of THC were identical across strains, under ei …
Vapor exposure to delta9-tetrahydrocannabinol (THC) slows locomotion of the Maine lobster (Homarus americanus).
Gutierrez A, Creehan KM, Turner ML, Tran RN, Kerr TM, Nguyen JD, Taffe MA. Gutierrez A, et al. Among authors: taffe ma. Pharmacol Biochem Behav. 2021 Aug;207:173222. doi: 10.1016/j.pbb.2021.173222. Epub 2021 Jun 29. Pharmacol Biochem Behav. 2021. PMID: 34197845 Free PMC article.
OBJECTIVE: The primary goal was to determine tissue THC levels in the lobster after exposure to THC vapor. Secondary goals were to determine if THC vapor altered locomotor behavior or nociception. ...RESULTS: THC vapor produced duration-related THC
OBJECTIVE: The primary goal was to determine tissue THC levels in the lobster after exposure to THC vapor. Secondary goals wer …
Vapor inhalation of cannabidiol (CBD) in rats.
Javadi-Paydar M, Creehan KM, Kerr TM, Taffe MA. Javadi-Paydar M, et al. Among authors: taffe ma. Pharmacol Biochem Behav. 2019 Sep;184:172741. doi: 10.1016/j.pbb.2019.172741. Epub 2019 Jul 20. Pharmacol Biochem Behav. 2019. PMID: 31336109 Free PMC article.
Appetitive, antinociceptive, and hypothermic effects of vaped and injected delta-9-tetrahydrocannabinol (THC) in rats: exposure and dose-effect comparisons by strain and sex.
Moore CF, Davis CM, Harvey EL, Taffe MA, Weerts EM. Moore CF, et al. Among authors: taffe ma. Pharmacol Biochem Behav. 2021 Mar;202:173116. doi: 10.1016/j.pbb.2021.173116. Epub 2021 Jan 23. Pharmacol Biochem Behav. 2021. PMID: 33493547 Free PMC article.
Plasma THC concentrations were assessed after THC vapor and 10 mg/kg IP THC. ...IP THC (3-20 mg/kg) reduced breakpoints. Vaped and injected THC produced exposure and dose-dependent antinociception and hypothermia. ...
Plasma THC concentrations were assessed after THC vapor and 10 mg/kg IP THC. ...IP THC (3-20 mg/kg) reduced brea …
Effects of delta9-THC and cannabidiol vapor inhalation in male and female rats.
Javadi-Paydar M, Nguyen JD, Kerr TM, Grant Y, Vandewater SA, Cole M, Taffe MA. Javadi-Paydar M, et al. Among authors: taffe ma. Psychopharmacology (Berl). 2018 Sep;235(9):2541-2557. doi: 10.1007/s00213-018-4946-0. Epub 2018 Jun 16. Psychopharmacology (Berl). 2018. PMID: 29907926 Free PMC article.
Plasma THC varied with the concentration in the PG vehicle but did not differ across rat sex. ...This confirms the efficacy of the e-cigarette-based method of THC delivery in female rats....
Plasma THC varied with the concentration in the PG vehicle but did not differ across rat sex. ...This confirms the efficacy of the e- …
Adult consequences of repeated nicotine and delta (9) -tetrahydrocannabinol (THC) vapor inhalation in adolescent rats.
Gutierrez A, Creehan KM, Grant Y, Taffe MA. Gutierrez A, et al. Among authors: taffe ma. bioRxiv [Preprint]. 2023 Sep 12:2023.09.08.556932. doi: 10.1101/2023.09.08.556932. bioRxiv. 2023. PMID: 37745433 Free PMC article. Updated. Preprint.
In contrast, THC exposed rats obtained volitional heroin vapor at rates indistinguishable from the non-THC-exposed groups. Repeated THC exposure also caused tolerance to temperature-disrupting effects of THC (5 mg/kg, i.p.). ...
In contrast, THC exposed rats obtained volitional heroin vapor at rates indistinguishable from the non-THC-exposed groups. Rep …
Inhaled delivery of delta(9)-tetrahydrocannabinol (THC) to rats by e-cigarette vapor technology.
Nguyen JD, Aarde SM, Vandewater SA, Grant Y, Stouffer DG, Parsons LH, Cole M, Taffe MA. Nguyen JD, et al. Among authors: taffe ma. Neuropharmacology. 2016 Oct;109:112-120. doi: 10.1016/j.neuropharm.2016.05.021. Epub 2016 May 30. Neuropharmacology. 2016. PMID: 27256501 Free PMC article.
THC). Female rats were more sensitive to hypothermic effects of 30 min of lower-dose THC inhalation. ...The plasma THC concentration after 30 min of inhalation was similar to that produced by 10 mg/kg THC i.p. ...
THC). Female rats were more sensitive to hypothermic effects of 30 min of lower-dose THC inhalation. ...The plasma THC
23 results