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Year Number of Results
2020 12
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2022 20
2023 9
2024 11

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Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.
Cantuti-Castelvetri L, Ojha R, Pedro LD, Djannatian M, Franz J, Kuivanen S, van der Meer F, Kallio K, Kaya T, Anastasina M, Smura T, Levanov L, Szirovicza L, Tobi A, Kallio-Kokko H, Österlund P, Joensuu M, Meunier FA, Butcher SJ, Winkler MS, Mollenhauer B, Helenius A, Gokce O, Teesalu T, Hepojoki J, Vapalahti O, Stadelmann C, Balistreri G, Simons M. Cantuti-Castelvetri L, et al. Science. 2020 Nov 13;370(6518):856-860. doi: 10.1126/science.abd2985. Epub 2020 Oct 20. Science. 2020. PMID: 33082293 Free PMC article.
The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ...Pathological analysis of olfactory epithelium obtained from human COVID-19 autopsies revealed that …
The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS …
SARS-CoV-2 and type 1 diabetes in children in Finland: an observational study.
Knip M, Parviainen A, Turtinen M, But A, Härkönen T, Hepojoki J, Sironen T, Iheozor-Ejiofor R, Uğurlu H, Saksela K, Lempainen J, Ilonen J, Vapalahti O; Finnish Pediatric Diabetes Register. Knip M, et al. Lancet Diabetes Endocrinol. 2023 Apr;11(4):251-260. doi: 10.1016/S2213-8587(23)00041-4. Lancet Diabetes Endocrinol. 2023. PMID: 36958868
In this study we aimed to evaluate the possible role of the SARS-CoV-2 virus in the reported increase in the rate of type 1 diabetes. ...Only five of those diagnosed during the pandemic (0.9%) of 583 tested positive for infection-induced SARS-CoV …
In this study we aimed to evaluate the possible role of the SARS-CoV-2 virus in the reported increase in the rate of ty …
COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants.
Jalkanen P, Kolehmainen P, Häkkinen HK, Huttunen M, Tähtinen PA, Lundberg R, Maljanen S, Reinholm A, Tauriainen S, Pakkanen SH, Levonen I, Nousiainen A, Miller T, Välimaa H, Ivaska L, Pasternack A, Naves R, Ritvos O, Österlund P, Kuivanen S, Smura T, Hepojoki J, Vapalahti O, Lempainen J, Kakkola L, Kantele A, Julkunen I. Jalkanen P, et al. Nat Commun. 2021 Jun 28;12(1):3991. doi: 10.1038/s41467-021-24285-4. Nat Commun. 2021. PMID: 34183681 Free PMC article.
As SARS-CoV-2 has been circulating for over a year, dozens of vaccine candidates are under development or in clinical use. ...The vaccinees' neutralization titres exceeded those of recovered non-hospitalized COVID-19 patients. Our work provides …
As SARS-CoV-2 has been circulating for over a year, dozens of vaccine candidates are under development or in clinical u …
SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase.
Kettunen P, Lesnikova A, Räsänen N, Ojha R, Palmunen L, Laakso M, Lehtonen Š, Kuusisto J, Pietiläinen O, Saber SH, Joensuu M, Vapalahti OP, Koistinaho J, Rolova T, Balistreri G. Kettunen P, et al. J Virol. 2023 Apr 27;97(4):e0014423. doi: 10.1128/jvi.00144-23. Epub 2023 Apr 11. J Virol. 2023. PMID: 37039676 Free PMC article.
2019 coronavirus disease (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ...SARS-CoV-2 infection of the human brain has been documented, but it is unclear whether the observed …
2019 coronavirus disease (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants.
Mäkelä AR, Uğurlu H, Hannula L, Kant R, Salminen P, Fagerlund R, Mäki S, Haveri A, Strandin T, Kareinen L, Hepojoki J, Kuivanen S, Levanov L, Pasternack A, Naves RA, Ritvos O, Österlund P, Sironen T, Vapalahti O, Kipar A, Huiskonen JT, Rissanen I, Saksela K. Mäkelä AR, et al. Nat Commun. 2023 Mar 24;14(1):1637. doi: 10.1038/s41467-023-37290-6. Nat Commun. 2023. PMID: 36964125 Free PMC article.
The emergence of increasingly immunoevasive SARS-CoV-2 variants emphasizes the need for prophylactic strategies to complement vaccination in fighting the COVID-19 pandemic. ...The potency and robust biochemical properties of TriSb92 together wit …
The emergence of increasingly immunoevasive SARS-CoV-2 variants emphasizes the need for prophylactic strategies to comp …
SARS-CoV-2 requires acidic pH to infect cells.
Kreutzberger AJB, Sanyal A, Saminathan A, Bloyet LM, Stumpf S, Liu Z, Ojha R, Patjas MT, Geneid A, Scanavachi G, Doyle CA, Somerville E, Correia RBDC, Di Caprio G, Toppila-Salmi S, Mäkitie A, Kiessling V, Vapalahti O, Whelan SPJ, Balistreri G, Kirchhausen T. Kreutzberger AJB, et al. Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2209514119. doi: 10.1073/pnas.2209514119. Epub 2022 Sep 1. Proc Natl Acad Sci U S A. 2022. PMID: 36048924 Free PMC article.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry starts with membrane attachment and ends with spike (S) protein-catalyzed membrane fusion depending on two cleavage steps, namely, one usually by furin in producing cells and the second b …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry starts with membrane attachment and ends with s …
Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response.
Lin JW, Tang C, Wei HC, Du B, Chen C, Wang M, Zhou Y, Yu MX, Cheng L, Kuivanen S, Ogando NS, Levanov L, Zhao Y, Li CL, Zhou R, Li Z, Zhang Y, Sun K, Wang C, Chen L, Xiao X, Zheng X, Chen SS, Zhou Z, Yang R, Zhang D, Xu M, Song J, Wang D, Li Y, Lei S, Zeng W, Yang Q, He P, Zhang Y, Zhou L, Cao L, Luo F, Liu H, Wang L, Ye F, Zhang M, Li M, Fan W, Li X, Li K, Ke B, Xu J, Yang H, He S, Pan M, Yan Y, Zha Y, Jiang L, Yu C, Liu Y, Xu Z, Li Q, Jiang Y, Sun J, Hong W, Wei H, Lu G, Vapalahti O, Luo Y, Wei Y, Connor T, Tan W, Snijder EJ, Smura T, Li W, Geng J, Ying B, Chen L. Lin JW, et al. Cell Host Microbe. 2021 Mar 10;29(3):489-502.e8. doi: 10.1016/j.chom.2021.01.015. Epub 2021 Jan 29. Cell Host Microbe. 2021. PMID: 33548198 Free PMC article.
The SARS-CoV-2 virus, the causative agent of COVID-19, is undergoing constant mutation. ...
The SARS-CoV-2 virus, the causative agent of COVID-19, is undergoing constant mutation. ...
The phylodynamics of SARS-CoV-2 during 2020 in Finland.
Truong Nguyen P, Kant R, Van den Broeck F, Suvanto MT, Alburkat H, Virtanen J, Ahvenainen E, Castren R, Hong SL, Baele G, Ahava MJ, Jarva H, Jokiranta ST, Kallio-Kokko H, Kekäläinen E, Kirjavainen V, Kortela E, Kurkela S, Lappalainen M, Liimatainen H, Suchard MA, Hannula S, Ellonen P, Sironen T, Lemey P, Vapalahti O, Smura T. Truong Nguyen P, et al. Commun Med (Lond). 2022 Jun 10;2:65. doi: 10.1038/s43856-022-00130-7. eCollection 2022. Commun Med (Lond). 2022. PMID: 35698660 Free PMC article.
However, compared to other European nations, Finland has had a low incidence of SARS-CoV-2. To gain insight into the origins and turnover of SARS-CoV-2 lineages circulating in Finland in 2020, we investigated the phylogeographic and -dyna …
However, compared to other European nations, Finland has had a low incidence of SARS-CoV-2. To gain insight into the or …
Spatiotemporal clustering patterns and sociodemographic determinants of COVID-19 (SARS-CoV-2) infections in Helsinki, Finland.
Siljander M, Uusitalo R, Pellikka P, Isosomppi S, Vapalahti O. Siljander M, et al. Spat Spatiotemporal Epidemiol. 2022 Jun;41:100493. doi: 10.1016/j.sste.2022.100493. Epub 2022 Feb 5. Spat Spatiotemporal Epidemiol. 2022. PMID: 35691637 Free PMC article.
This study aims to elucidate the variations in spatiotemporal patterns and sociodemographic determinants of SARS-CoV-2 infections in Helsinki, Finland. Global and local spatial autocorrelation were inspected with Moran's I and LISA statistics, and Getis-Ord G …
This study aims to elucidate the variations in spatiotemporal patterns and sociodemographic determinants of SARS-CoV-2 …
Intranasal administration of adenoviral vaccines expressing SARS-CoV-2 spike protein improves vaccine immunity in mouse models.
Freitag TL, Fagerlund R, Karam NL, Leppänen VM, Ugurlu H, Kant R, Mäkinen P, Tawfek A, Jha SK, Strandin T, Leskinen K, Hepojoki J, Kesti T, Kareinen L, Kuivanen S, Koivulehto E, Sormunen A, Laidinen S, Khattab A, Saavalainen P, Meri S, Kipar A, Sironen T, Vapalahti O, Alitalo K, Ylä-Herttuala S, Saksela K. Freitag TL, et al. Vaccine. 2023 May 11;41(20):3233-3246. doi: 10.1016/j.vaccine.2023.04.020. Epub 2023 Apr 14. Vaccine. 2023. PMID: 37085458 Free PMC article.
We found that a single intranasal (i.n.) dose of serotype-5 adenoviral vectors expressing either the receptor binding domain (Ad5-RBD) or the complete ectodomain (Ad5-S) of the SARS-CoV-2 spike protein was effective in inducing i) serum and bronchoalveolar la …
We found that a single intranasal (i.n.) dose of serotype-5 adenoviral vectors expressing either the receptor binding domain (Ad5-RBD) or th …
63 results